Crinone (Progesterone)

Crinone (progesterone) is a vaginal gel containing progesterone used as a treatment for infertile women with progesterone deficiency.

Indications for use

  • Maintaining the luteal phase in the process of applying assisted reproduction methods;
  • Secondary amenorrhea, dysfunctional uterine bleeding due to progesterone deficiency;
  • Hormone replacement therapy in postmenopausal women (in combination with estrogen drugs).

How does it work?

Progesterone is a corpus luteum hormone. It causes the transition of the uterine mucosa from the proliferation phase caused by FSH to the secretory phase. It reduces the excitability and contractility of the muscles of the uterus and fallopian tubes. Progesterone inhibits the secretion of hypothalamic FSH and LH release factors, inhibits the formation of gonadotropin hormones in the pituitary gland and inhibits ovulation. Progesterone in the form of a vaginal gel is included in the polymer delivery system, which binds to the vaginal mucosa and guarantees a constant release of the drug for at least 3 days.

How to use Crinone?

The application should be performed in accordance with this instruction:

  • Take the applicator by tightly holding its upper end between the thumb and forefinger. Shake the applicator like a medical thermometer so that the gel moves to the lower end of the applicator;
  • Hold the applicator by the upper flat end of the air container, remove the breakable lid from the opposite end by turning. Do not press on the air container;
  • The applicator can be introduced both in the sitting position and in the supine position with slightly bent knees. Carefully insert the lower end of the applicator into the vagina;
  • Squeeze the air container so that the gel from the applicator gets into the vagina. Despite the fact that a certain amount of gel remains in the applicator, the patient receives the necessary dose. Then you can discard the applicator with the remainder of the gel in it. The gel covers the vaginal mucosa, providing a prolonged release of progesterone.


Do not use Crinone gel if you have any of the following conditions:

  • nodal forms of fibrocystic mastopathy;
  • tumors (tumor-like formations) of mammary glands;
  • breast cancer monotherapy;
  • genital cancer monotherapy;
  • II and III trimesters of pregnancy;
  • individual hypersensitivity to the components of the drug.

With caution: liver failure, renal failure, bronchial asthma, epilepsy, migraine, depression, hyperlipoproteinemia, ectopic pregnancy, abortion, tendency to thrombosis, with acute forms of phlebitis or thromboembolic diseases, bleeding from unknown etiology, porphyria, arterial hypertension, diabetes mellitus.

Pregnancy and lactation

There is not enough experience with the use of Crinone during pregnancy.

The use of progesterone gel during pregnancy and lactation is only possible if the intended benefit to the mother outweighs the potential risk to the fetus and child.

Side effects

In some cases, Crinone can cause the following side effects: headache, drowsiness, abdominal pain, tenderness of the mammary glands, hypersensitivity reactions (skin rash), intermenstrual bleeding, irritation of the vaginal mucosa and other local reactions of moderate severity in the area of application.


Currently, cases of overdose have not been reported.

Interaction with other drugs

The use of Crinone gel together with other intravaginal agents is not recommended.

Special instructions

The drug can be used for mastodynia associated with taking oral contraceptives, puberty, premenopause, premenstrual tension syndrome.

The drug should be applied to the skin of the mammary gland with a metering applicator, without rubbing or massaging the mammary glands.

After applying the cream, direct sunlight should be avoided.

Studies to identify the possible effect of the drug on the ability to drive a car or on the ability to control mechanisms have not been conducted.

How to store Crinone?

Store the drug at room temperature away from moisture, heat, and light.