Gonal–f® RFF Pen

The Gonal–f® RFF Pen is for women seeking pregnancy and is used to help ovaries make more eggs. It is used in Ovulation Induction (OI) and in vitro fertilization (IVF), to supplement a woman’s naturally occurring follicle stimulating hormone (FSH).

Priming the pen: First use only

Attach needle. Set dose arrow at 37.5. Pull out injection button as far as it will go. Remove inner needle cap and hold pen so needle points upward. Tap prefilled reservoir to let any air bubbles rise to the top. (It’s normal if a few small air bubbles remain.)

Keep needle pointing upward and push in injection button completely. Hold until you hear a click. A small amount of liquid should appear from needle tip. (If no liquid comes out, reprime the pen until it does.) Replace inner needle cap.

Step-by-step instructions for using the Gonal-f® RFF Pen

Remove pen cap and wipe threaded tip with alcohol swab.

Remove peel tab from outer needle cap.

Press threaded tip of pen into open end of outer needle cap. Twist pen clockwise until needle is securely attached.

Remove outer needle cap.

Turn dosage dial so your prescribed dose is lined up with the black dose arrow.

Recheck that correct dose on the dosage dial is lined up with black dose arrow before proceeding. If the dialed dose is too high or too low, reset before pulling the injection button.

Load the dose by pulling out injection button as far as it will go. Find the last fully visible flat red arrow on the injection button. It confirms the dose that is loaded and ready to be injected. (If the loaded dose is lower than the set dose, there is not enough drug to complete the dose. Use a new Gonal-f® RFF Pen to complete dose.

Clean recommended injection site with alcohol swab and let air-dry. Remove inner needle cap. Do not touch needle or allow it to touch any surface. Inject needle into skin at a 90° angle. Push the injection button until it stops clicking. After the last click, keep the needle in the skin for at least 5 seconds. Remove the needle and apply pressure as needed with a gauze pad.


Hold pen firmly by drug reservoir and replace outer needle cap. Grip outer needle cap firmly, and unscrew pen from needle by turning pen counterclockwise. Dispose of needle in safety container.


After use, replace pen cap and store pen at room temperature or in refrigerator for up to 28 days.


For more product details or more detailed injection information please see Health Banks